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Characters · Protagonist Lucia Caminos Half of the playable duo and the first GTA lead woman with a full voice. Raised in Liberty City by a father who put boxing gloves on her before most kids get a bike, she took the fall defending her family and walked into Leonida Penitentiary — then walked out on a lucky break. Jason might be her ticket to the life her mom always wanted. 
Characters · Protagonist Jason Duval The other half of the duo. Grew up surrounded by small-time hustlers, escaped into the Army, and came out the other side running product for drug smugglers in the Leonida Keys. He crashes rent-free in a Key Lento stilt house owned by Brian Heder — payment comes in shakedown work. Wants a quiet life; keeps not getting one. 
Characters · Major character Cal Hampton Jason's friend and coworker at Brian's boatyard. A happy conspiracy theorist who'd rather stay home with a beer, a police scanner, and the Coast Guard frequency than go anywhere. Rockstar pitches him as living at the low tide of America — and loving it. 
Characters · Major character Boobie Ike Vice City royalty who converted street credibility into a legitimate portfolio: real estate, the Jack of Hearts strip club, and a recording studio. His heart is in Only Raw Records, the label he runs with Dre'Quan Priest. 
Characters · Major character Dre'Quan Priest A hustler who always saw dealing as a means and music as the end. Started out booking acts into Boobie's club; now runs Only Raw Records and just signed Real Dimez, aiming straight at the heart of Vice City's music scene. 
Characters · Major character Real Dimez Roxy and Bae-Luxe — best friends since high school who monetized chaos: first shaking down local dealers, then flipping the lifestyle into rap tracks and a relentless social feed. An early hit with Vice City rapper DWNPLY put them on the map; Only Raw Records wants lightning to strike twice. 
Characters · Major character Raul Bautista A veteran bank robber with charm to spare and a recruiting eye for people willing to gamble big. Every job he plans raises the stakes a little higher — eventually his crew will have to go all-in or walk away. 
Characters · Major character Brian Heder A relic of the golden age of Keys smuggling who never retired — he just got a boatyard. Still moves product through Brian's Boat Works & Marina with Lori, wife number three, and lets Jason live on his property in exchange for dirty work. Looks like a beach bum, operates like a shark.